Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600764 | 0.75 | ADORA2A (0.40) | ADORA2AADORA1ARCNR1GSK3B | |
| SCHEMBL14600762 | 0.75 | ADORA2A (0.40) | ADORA2AADORA1ARCNR1GSK3B | |
| SCHEMBL14600758 | 0.69 | GSK3B (0.41) | ADORA2AADORA1ARCNR1GSK3B | |
| SCHEMBL14600765 | 0.69 | ADORA2A (0.41) | ADORA2AADORA1ARCNR1CCNA2 | |
| SCHEMBL14286135 | 0.65 | ROCK2 (0.41) | ADORA2AADORA1GSK3BCCNA2CDK2 | |
| SCHEMBL14286139 | 0.65 | ROCK2 (0.40) | ADORA2AADORA1GSK3BCCNA2CDK2 | |
| SCHEMBL10067974 | 0.64 | CHRM1 (0.40) | ADORA2AADORA1ARCNR1CCNA2 | |
| SCHEMBL14600763 | 0.64 | GSK3B (0.44) | GSK3BKCNH2KMT2AMEN1 | |
| SCHEMBL10067975 | 0.64 | ALDH1A1 (0.46) | GSK3BKCNH2KMT2AMEN1 | |
| SCHEMBL10067976 | 0.64 | GSK3B (0.44) | GSK3BKCNH2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697352-B1 | 4-AZOLE SUBSTITUTED IMIDAZOLE COMPOSITIONS USEFUL AS INHIBITORS OR C-MET RECEPTOR TYROSINE KINASE | VERTEX PHARMA (US) | 2012-06-27 | — | — | EP | disclosed |