Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903982 | 0.81 | GPR119 (0.47) | GPR119NPC1RAB9ASMN1; SMN2RXRA | |
| SCHEMBL10067567 | 0.74 | GPR119 (0.42) | GPR119SLC6A7MEN1KMT2A | |
| SCHEMBL3342687 | 0.72 | GPR119 (0.52) | GPR119RXRARXRBSRD5A2SSTR5 | |
| SCHEMBL904162 | 0.71 | GPR119 (0.45) | GPR119ALDH1A1MAPTKMT2ATP53 | |
| SCHEMBL904161 | 0.71 | GPR119 (0.45) | GPR119ALDH1A1MAPTKMT2ATP53 | |
| SCHEMBL15110025 | 0.69 | GPR119 (0.49) | GPR119RXRARXRBMAPTSLC6A7 | |
| SCHEMBL10068007 | 0.68 | GPR119 (0.52) | GPR119NPC1RAB9ASMN1; SMN2MAPT | |
| Oxalic Acid SCHEMBL15110141 | 0.67 | GPR119 (0.47) | GPR119RXRARXRBMAPTLTA4H | |
| SCHEMBL903911 | 0.67 | KDM4E (0.36) | GPR119NPC1RAB9A | |
| SCHEMBL25677913 | 0.67 | POLB (0.59) | GPR119NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |