Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.52 |
| ▸ | ACACB | O00763 | 4/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3341593 | 0.90 | GPR119 (0.51) | GPR119ACACBADRB2MEN1KMT2A | |
| SCHEMBL3343984 | 0.89 | ACACB (0.52) | GPR119ACACBADRB2MEN1KMT2A | |
| SCHEMBL8515468 | 0.81 | GPR119 (0.53) | GPR119ACACB | |
| SCHEMBL8537179 | 0.80 | GPR119 (0.42) | GPR119ACACB | |
| SCHEMBL15110025 | 0.80 | GPR119 (0.49) | GPR119MEN1KMT2ARXRARXRB | |
| SCHEMBL8513552 | 0.79 | GPR119 (0.51) | GPR119ACACB | |
| Oxalic Acid SCHEMBL15110141 | 0.78 | GPR119 (0.47) | GPR119MEN1KMT2ARXRARXRB | |
| SCHEMBL12239173 | 0.78 | GPR119 (0.48) | GPR119ACACBADRB2MEN1KMT2A | |
| SCHEMBL25677913 | 0.77 | POLB (0.59) | GPR119MEN1KMT2A | |
| SCHEMBL3346772 | 0.76 | GPR119 (0.47) | GPR119ACACBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |