Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903884 | 0.81 | KIF11 (0.41) | PTGS2KIF11PTGS1BRD4 | |
| SCHEMBL903936 | 0.79 | GPR119 (0.48) | — | |
| SCHEMBL10067699 | 0.79 | NR1H2 (0.40) | PTGS2KIF11PTGS1 | |
| SCHEMBL904082 | 0.78 | GPR119 (0.47) | PTGS2 | |
| SCHEMBL903891 | 0.78 | GPR119 (0.47) | PTGS2 | |
| SCHEMBL10067702 | 0.77 | GPR119 (0.45) | PTGS2 | |
| SCHEMBL10068069 | 0.77 | GPR119 (0.45) | PTGS2 | |
| SCHEMBL903897 | 0.76 | GPR119 (0.40) | PTGS2KIF11PTGS1 | |
| SCHEMBL10067575 | 0.76 | GPR119 (0.47) | PTGS2PTGS1LRRK2 | |
| SCHEMBL904103 | 0.75 | NR1H2 (0.41) | PTGS2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |