Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.83 |
| ▸ | MEN1 | O00255 | 8/20 | 0.83 |
| ▸ | NPC1 | O15118 | 3/20 | 0.78 |
| ▸ | RAB9A | P51151 | 3/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | POLB | P06746 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | AHR | P35869 | 1/20 | 0.72 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.71 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632076 | 0.87 | NPC1 (1.00) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6633618 | 0.85 | KMT2A (0.89) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2534117 | 0.84 | KMT2A (1.00) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23011774 | 0.83 | ALDH1A1 (0.84) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14006936 | 0.81 | NPC1 (0.70) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10069470 | 0.81 | KCNK9 (0.81) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12228183 | 0.81 | NPC1 (0.83) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4256368 | 0.81 | NPC1 (1.00) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17712432 | 0.80 | KCNK3 (0.82) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1336753 | 0.79 | ALDH1A1 (0.75) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |