Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162285 | 0.91 | NPC1 (0.83) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL10069472 | 0.87 | KMT2A (0.83) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL2535208 | 0.86 | MAPT (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL23011774 | 0.85 | ALDH1A1 (0.84) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL2534117 | 0.84 | KMT2A (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL1336753 | 0.84 | ALDH1A1 (0.75) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL6633618 | 0.84 | KMT2A (0.89) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL3996393 | 0.84 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL14006936 | 0.83 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL2624525 | 0.83 | MAPT (0.76) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | claimed |
| EP-1453828-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | AstraZeneca AB (SE) | 2004-09-08 | — | — | EP | disclosed |
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |
| WO-2003032897-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | ASTRAZENECA AB (SE) | 2003-04-24 | — | — | WO | disclosed |