Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.73 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069463 | 0.99 | KCNK9 (0.70) | KCNK9KCNK3KMT2AMEN1NPC1 | |
| SCHEMBL10069443 | 0.96 | KCNK9 (0.67) | KCNK9KCNK3KMT2AMEN1NPC1 | |
| SCHEMBL10069469 | 0.94 | KCNK9 (0.71) | KCNK9KCNK3KMT2AMEN1NPC1 | |
| SCHEMBL25938747 | 0.84 | MTNR1A (0.71) | KMT2AMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL30605277 | 0.84 | MTNR1A (0.71) | KMT2AMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL12302912 | 0.83 | MTNR1A (0.73) | KMT2AMEN1NPC1ALDH1A1TP53 | |
| SCHEMBL3188745 | 0.81 | ENPP3 (0.69) | KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5205624 | 0.80 | NPC1 (0.69) | KMT2AMEN1NPC1RAB9A | |
| SCHEMBL1342152 | 0.79 | MEN1 (0.60) | KCNK9KCNK3KMT2AMEN1NPC1 | |
| SCHEMBL12228183 | 0.79 | NPC1 (0.83) | KCNK9KCNK3KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |