Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.67 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.65 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | STS | P08842 | 1/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3188745 | 0.98 | ENPP3 (0.69) | NPC1RAB9AENPP3ENPP1HTT | |
| SCHEMBL8324607 | 0.93 | MTNR1A (0.71) | NPC1RAB9AHTTMTNR1AMTNR1B | |
| SCHEMBL18877691 | 0.90 | RAB9A (0.64) | NPC1RAB9AENPP3ENPP1HTT | |
| SCHEMBL18877692 | 0.90 | RAB9A (0.64) | NPC1RAB9AENPP3ENPP1HTT | |
| SCHEMBL3995294 | 0.89 | ENPP3 (0.59) | NPC1RAB9AENPP3ENPP1HTT | |
| SCHEMBL30518933 | 0.87 | MTNR1A (0.64) | NPC1RAB9AHTTMTNR1AMTNR1B | |
| SCHEMBL8199064 | 0.86 | SMN1; SMN2 (0.64) | NPC1RAB9AHTTMTNR1AMTNR1B | |
| SCHEMBL3197659 | 0.86 | MTNR1A (0.63) | NPC1RAB9AHTTMTNR1AMTNR1B | |
| SCHEMBL3197669 | 0.86 | MTNR1A (0.63) | NPC1RAB9AHTTMTNR1AMTNR1B | |
| SCHEMBL18951296 | 0.85 | NPC1 (0.60) | NPC1RAB9AENPP3ENPP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |