SCHEMBL10069632

SCHEMBL10069632

CCc1c(-c2ccccc2)n(COCc2ccccc2)c(=O)n(O)c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.40
POLB P06746 2/20 0.40
RECQL P46063 1/20 0.40
KDM5B Q9UGL1 1/20 0.38
MAPK14 Q16539 1/20 0.38
HTT P42858 1/20 0.37
MAPT P10636 3/20 0.37
ERCC5 P28715 2/20 0.36
FEN1 P39748 2/20 0.36
CNOT7 Q9UIV1 2/20 0.36
ERCC1 P07992 1/20 0.36
ERCC4 Q92889 1/20 0.36
RAB9A P51151 3/20 0.35
STAT1 P42224 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ATM Q13315 1/20 0.35
ADORA2B P29275 1/20 0.34
ADORA1 P30542 1/20 0.34
KDM5A P29375 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10069623 0.93 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2POLBRECQLMAPK14
SCHEMBL10069621 0.92 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2MAPK14HTTMAPT
SCHEMBL1287915 0.92 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2POLBRECQLMAPK14
SCHEMBL10069613 0.90 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2POLBRECQLHTT
SCHEMBL10069625 0.90 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2POLBRECQLKDM5B
SCHEMBL10069600 0.88 AR (0.42) ALDH1A1POLBHTTRAB9AADORA2B
SCHEMBL10069630 0.88 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2POLBRECQLKDM5B
SCHEMBL1687638 0.86 ADORA2A (0.36) ALDH1A1MAPTADORA2BADORA1
SCHEMBL10069615 0.84 ERCC5 (0.39) ALDH1A1SMN1; SMN2POLBMAPK14HTT
SCHEMBL10069612 0.84 ALDH1A1 (0.37) ALDH1A1SMN1; SMN2POLBRECQLMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012047993-A2 N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2012-04-12 WO disclosed