Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 11/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21031807 | 0.78 | GLA (0.45) | MTORMAP3K12PIK3CDTNFPIK3CA | |
| SCHEMBL29601287 | 0.78 | GLA (0.45) | MTORMAP3K12PIK3CDTNFPIK3CA | |
| SCHEMBL18072106 | 0.77 | MTOR (0.40) | MTORMAP3K12PIK3CDTNFPIK3CA | |
| SCHEMBL3643010 | 0.77 | ALDH1A1 (0.43) | MTORMAP3K12TNFPIK3CAPOLB | |
| SCHEMBL503280 | 0.75 | IDO1 (0.43) | MTORMAP3K12PIK3CDTNFPIK3CA | |
| SCHEMBL17619923 | 0.75 | HPGD (0.32) | PIK3CD | |
| SCHEMBL182671 | 0.75 | HTT (0.54) | MTORMAP3K12TNFPIK3CAPOLB | |
| SCHEMBL11890838 | 0.75 | NOS3 (0.54) | MTORMAP3K12PIK3CDPIK3CA | |
| SCHEMBL13186700 | 0.75 | PIK3CD (0.34) | PIK3CD | |
| SCHEMBL1583813 | 0.75 | IDO1 (0.43) | MTORMAP3K12PIK3CDTNFPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |
| WO-2010091409-A1 | CERTAIN NITROGEN CONTAINING BICYCLIC CHEMICAL ENTITIES FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2010-08-12 | — | — | WO | disclosed |