Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.67 |
| ▸ | CNR2 | P34972 | 3/20 | 0.65 |
| ▸ | HTR1B | P28222 | 7/20 | 0.64 |
| ▸ | HTR1D | P28221 | 2/20 | 0.64 |
| ▸ | CNR1 | P21554 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438840 | 1.00 | KCNA3 (0.67) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| SCHEMBL8955863 | 1.00 | KCNA3 (0.67) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| SCHEMBL4647042 | 1.00 | KCNA3 (0.67) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| SCHEMBL8544058 | 1.00 | KCNA3 (0.67) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| SCHEMBL6272756 | 0.98 | KCNA3 (0.69) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| SCHEMBL3607496 | 0.93 | HTR1B (0.68) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| Hydrochloric Acid SCHEMBL28443504 | 0.91 | HTR1B (0.66) | KCNA3CNR2HTR1BHTR1DCNR1 | |
| SCHEMBL16902853 | 0.91 | KCNA3 (0.79) | KCNA3HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL16902840 | 0.91 | KCNA3 (0.79) | KCNA3HTR1BHTR1DSLC6A4HRH1 | |
| SCHEMBL16902854 | 0.91 | KCNA3 (0.79) | KCNA3HTR1BHTR1DSLC6A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268606-B1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-08-06 | — | — | EP | disclosed |
| US-8344027-B2 | 4-dimethylaminobutyric acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20120289554-A1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | ANDJELKOVIC MIRJANA (CH) | 2012-11-15 | — | — | US | disclosed |
| EP-2268606-A1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009132978-A1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | disclosed |
| US-20090270505-A1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270505-A1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | CPT1B, CPT1A, CPT2 | KCNA3 3178/4885CNR2 311/4885HTR1B 658/4885 |
| US-20120289554-A1 | 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES | CPT1B, CPT1A, CPT2 | KCNA3 3178/4885CNR2 311/4885HTR1B 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.