Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.63 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709233 | 0.82 | ALDH1A1 (0.51) | KMT2AGAAALDH1A1TSHRNPSR1 | |
| SCHEMBL1709232 | 0.78 | SCN9A (1.00) | SCN9AKCNQ2KMT2AGAAPKM | |
| SCHEMBL7540788 | 0.71 | ALDH1A1 (0.55) | KCNQ2KMT2AGAAPKMALDH1A1 | |
| SCHEMBL13167010 | 0.69 | KCNQ2 (1.00) | KCNQ2KMT2AGAAPKMALDH1A1 | |
| SCHEMBL4318899 | 0.68 | KCNQ2 (0.68) | KCNQ2KMT2AGAAPKMALDH1A1 | |
| SCHEMBL2796459 | 0.68 | HRH3 (1.00) | KMT2AHRH3ALDH1A1MEN1KDM4E | |
| SCHEMBL29559749 | 0.68 | KCNQ2 (0.68) | KCNQ2KMT2AGAAPKMALDH1A1 | |
| SCHEMBL29957640 | 0.68 | KMT2A (0.72) | KCNQ2KMT2AGAAPKMALDH1A1 | |
| SCHEMBL22897679 | 0.68 | KCNQ2 (0.68) | KCNQ2KMT2AGAAPKMALDH1A1 | |
| SCHEMBL18838361 | 0.67 | HRH3 (0.51) | KMT2APKMHRH3MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |