Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 1.00 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709235 | 0.80 | SCN9A (0.66) | SCN9ANAMPTKMT2ATSHRMEN1 | |
| SCHEMBL1709247 | 0.78 | SCN9A (0.64) | SCN9ANAMPTKMT2ATSHRCYP3A4 | |
| SCHEMBL10072039 | 0.78 | SCN9A (0.63) | SCN9AKCNQ2KMT2AGAAPKM | |
| SCHEMBL1709234 | 0.75 | SCN9A (0.60) | SCN9ANAMPTKMT2AACHEBACE1 | |
| SCHEMBL1709211 | 0.74 | SCN9A (0.59) | SCN9ANAMPTKMT2AGAAACHE | |
| SCHEMBL1709213 | 0.74 | SCN9A (0.58) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL10071962 | 0.73 | SCN9A (0.57) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL10072406 | 0.73 | SCN9A (0.57) | SCN9ANAMPTKMT2AACHEBACE1 | |
| SCHEMBL10071963 | 0.72 | SCN9A (0.56) | SCN9ANAMPTKMT2AGAAACHE | |
| SCHEMBL1479354 | 0.71 | ADRA1A (0.58) | SCN9AKCNQ2KMT2AGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |