Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | PAM | P19021 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15315162 | 0.85 | IDO1 (0.47) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL10510400 | 0.84 | PAM (0.58) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL9857863 | 0.84 | PAM (0.58) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL18444843 | 0.84 | IDO1 (0.46) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL7366215 | 0.81 | IDO1 (0.47) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL7366213 | 0.81 | IDO1 (0.47) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL10509109 | 0.81 | IDO1 (0.55) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL9857835 | 0.81 | IDO1 (0.55) | IDO1PAMMMP1MMP2MMP9 | |
| SCHEMBL22064200 | 0.79 | NPC1 (0.47) | IDO1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL9857423 | 0.79 | IDO1 (0.47) | IDO1PAMMMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017021384-A1 | ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-09 | — | — | WO | disclosed |
| US-20130272978-A1 | DIHYDROXYACETONE MONOETHERS | MERCK PATENT GMBH (DE) | 2013-10-17 | — | — | US | disclosed |
| WO-2012084121-A1 | DIHYDROXYACETONE MONOETHER | MERCK PATENT GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130272978-A1 | DIHYDROXYACETONE MONOETHERS | GNPAT, UGT1A7, UGT1A3 | IDO1 1295/4885PAM 907/4885MMP1 2104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.