Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730641 | 0.83 | KDM4E (0.49) | MAPK1KDM4EMAPTNPSR1CYP1A2 | |
| SCHEMBL4397644 | 0.77 | KDM4E (0.62) | MAPK1KDM4EMAPTNPSR1CYP1A2 | |
| SCHEMBL2724206 | 0.76 | CYP1A2 (0.47) | ENPP1MAPK1KDM4EMAPTNPSR1 | |
| SCHEMBL4761441 | 0.75 | KDM1A (0.56) | AURKAPDGFRBEGFRKITPDE10A | |
| SCHEMBL31452625 | 0.74 | MTNR1B (0.50) | ENPP1MAPK1KDM4EMAPTNPSR1 | |
| SCHEMBL5461664 | 0.74 | PDE10A (0.54) | AURKAPDGFRBEGFRKITPDE10A | |
| SCHEMBL30734153 | 0.73 | HTT (0.59) | KDM4ENPSR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2725752 | 0.73 | PDGFRB (0.48) | MAPK1KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4406170 | 0.72 | ACHE (0.58) | ENPP1PDGFRBEGFRKITPDE10A | |
| SCHEMBL31452546 | 0.72 | MTNR1B (0.52) | ENPP1MAPK1KDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| EP-2632923-B1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | RAB1A, PIK3R5, PIK3R1 | ENPP1 2515/4885MAPK1 25/4885KDM4E 4345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.