Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474663 | 0.86 | HSD11B1 (0.41) | HSD11B1P2RX7ROCK2 | |
| SCHEMBL474662 | 0.86 | HSD11B1 (0.41) | HSD11B1P2RX7ROCK2 | |
| SCHEMBL474703 | 0.86 | HSD11B1 (0.41) | HSD11B1P2RX7ROCK2 | |
| SCHEMBL10072596 | 0.86 | HSD11B1 (0.41) | HSD11B1P2RX7ROCK2 | |
| SCHEMBL13955304 | 0.83 | HSD11B1 (0.37) | HSD11B1ROCK2 | |
| SCHEMBL13955036 | 0.80 | HSD11B1 (0.38) | HSD11B1P2RX7ROCK2 | |
| SCHEMBL2990514 | 0.77 | P2RX7 (0.44) | HSD11B1P2RX7 | |
| SCHEMBL2995839 | 0.77 | P2RX7 (0.44) | HSD11B1P2RX7 | |
| SCHEMBL3879672 | 0.77 | CYP2A13 (0.46) | HSD11B1P2RX7 | |
| SCHEMBL2996038 | 0.77 | P2RX7 (0.44) | HSD11B1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-B1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | disclosed |