Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474663 | 1.00 | HSD11B1 (0.41) | HSD11B1OPRM1CCR5P2RX7ROCK2 | |
| SCHEMBL474703 | 1.00 | HSD11B1 (0.41) | HSD11B1OPRM1CCR5P2RX7ROCK2 | |
| SCHEMBL2998485 | 0.89 | HSD11B1 (0.41) | HSD11B1OPRM1CCR5P2RX7ROCK2 | |
| SCHEMBL2996001 | 0.89 | HSD11B1 (0.41) | HSD11B1OPRM1CCR5P2RX7ROCK2 | |
| SCHEMBL2990822 | 0.89 | HSD11B1 (0.54) | HSD11B1OPRM1P2RX7ROCK2 | |
| SCHEMBL10072596 | 0.88 | HSD11B1 (0.41) | HSD11B1OPRM1P2RX7ROCK2 | |
| SCHEMBL2208101 | 0.88 | HSD11B1 (0.41) | HSD11B1OPRM1CCR5P2RX7ROCK2 | |
| SCHEMBL13675621 | 0.87 | HSD11B1 (0.39) | HSD11B1OPRM1P2RX7ROCK2HTR1A | |
| SCHEMBL2999375 | 0.86 | HSD11B1 (0.39) | HSD11B1OPRM1P2RX7ROCK2HTR1A | |
| SCHEMBL2989266 | 0.86 | HSD11B1 (0.39) | HSD11B1OPRM1P2RX7ROCK2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-B1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | claimed |
| US-7998999-B2 | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2011-08-16 | — | — | US | claimed |
| CN-101432262-B | Cyclohexyl-substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI | 2011-06-01 | — | — | CN | claimed |
| US-20090239911-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY | 2009-09-24 | — | — | US | claimed |
| EP-2049475-B1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | disclosed |
| US-7998999-B2 | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2011-08-16 | — | — | US | disclosed |
| CN-101432262-B | Cyclohexyl-substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI | 2011-06-01 | — | — | CN | disclosed |
| US-20090239911-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY | 2009-09-24 | — | — | US | disclosed |
| CN-101432262-A | Cyclohexyl-substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI (US) | 2009-05-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239911-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885OPRM1 1439/4885CCR5 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.