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SCHEMBL10072811

SCHEMBL10072811

C/C(C#N)=C1/c2cc(-c3cc(C)cc(C(F)(F)F)c3)ccc2-c2nc3c(nc21)-c1ccc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1/C3=C(/C)C#N

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 4/20 0.36
▸ RXRB P28702 3/20 0.36
▸ CTSS P25774 2/20 0.35
▸ CTSK P43235 2/20 0.35
▸ RXRG P48443 3/20 0.34
▸ NOTUM Q6P988 1/20 0.32
▸ XDH P47989 2/20 0.32
▸ AR P10275 1/20 0.30
▸ ADCY8 P40145 1/20 0.30
▸ ADCY1 Q08828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2756293 0.88 RXRA (0.36) RXRARXRBCTSSCTSKRXRG
SCHEMBL1755054 0.86 KIF11 (0.39) CTSSCTSKXDH
SCHEMBL12148669 0.83 RXRA (0.33) RXRARXRBCTSSCTSKRXRG
SCHEMBL22966126 0.82 RXRA (0.36) RXRARXRBCTSSCTSKRXRG
SCHEMBL10072958 0.82 CTSS (0.37) RXRARXRBCTSSCTSKRXRG
SCHEMBL15779890 0.82 CTSS (0.37) RXRARXRBCTSSCTSKRXRG
SCHEMBL12149290 0.82 RXRA (0.35) RXRARXRBCTSSCTSKRXRG
SCHEMBL2755915 0.82 RXRA (0.35) RXRARXRBCTSSCTSKRXRG
SCHEMBL16433753 0.81 CTSS (0.39) RXRARXRBCTSSCTSKRXRG
SCHEMBL12149288 0.80 RXRA (0.36) RXRARXRBCTSSCTSKRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2213662-B1 AZAINDENOFLUORENEDIONE DERIVATIVE, ORGANIC ELECTROLUMINESCENT DEVICE MATERIAL, AND ORGANIC ELECTROLUMINESCENT DEVICE IDEMITSU KOSAN CO (JP) 2012-04-18 — — EP disclosed