Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535782 | 0.89 | SYK (0.52) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL8238491 | 0.88 | SYK (0.61) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL644883 | 0.86 | SYK (0.50) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL8180866 | 0.83 | SYK (0.56) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL8167921 | 0.83 | SYK (0.56) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL25391654 | 0.83 | SYK (0.56) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL421286 | 0.83 | SYK (0.61) | SYKMEN1KMT2AALDH1A1CA12 | |
| SCHEMBL2141676 | 0.82 | ALDH1A1 (0.51) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL6046926 | 0.81 | SYK (0.54) | SYKMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL27190527 | 0.81 | SMN1; SMN2 (0.57) | SYKMEN1KMT2AL3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217928-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2024-07-04 | — | — | US | disclosed |
| CN-117813284-A | Halogenated acethydrazide as AEP inhibitor | 豪夫迈·罗氏有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2023006645-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-02-02 | — | — | WO | disclosed |
| WO-2018234483-A1 | TUNABLE PROBES FOR SELECTIVE PROTEIN LABELLING AND ENZYME INHIBITION | AAA CHEMISTRY APS (DK) | 2018-12-27 | — | — | WO | disclosed |
| US-20120010161-A1 | NOVEL AZAPEPTIDE OR AZAPEPTIDOMIMETIC COMPOUNDS INHIBITING BCRP AND/OR P-GP | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010161-A1 | NOVEL AZAPEPTIDE OR AZAPEPTIDOMIMETIC COMPOUNDS INHIBITING BCRP AND/OR P-GP | ABCB1, ABCB11, ABCC1 | SYK 1230/4885MEN1 4401/4885KMT2A 1829/4885 |
| US-20240217928-A1 | HALOACETHYDRAZIDES USEFUL AS AEP INHIBITORS | NHERF1, ENPP1, ATP6AP1 | SYK 4755/4885MEN1 1657/4885KMT2A 2938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.