Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2208705 | 0.85 | SSTR5 (0.43) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL21946568 | 0.84 | ROCK1 (0.37) | CFDKMT2AMEN1ALDH1A1PTGER1 | |
| SCHEMBL25940512 | 0.71 | CFD (0.37) | CFDKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2212451 | 0.71 | SSTR5 (0.49) | KMT2AMEN1ALDH1A1PTGER1RAB9A | |
| SCHEMBL17321437 | 0.71 | P2RX7 (0.39) | KMT2AMEN1PTGER1BRD4 | |
| SCHEMBL13844069 | 0.71 | HTR3A (0.41) | SMN1; SMN2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL3957542 | 0.71 | HTR3A (0.41) | ALDH1A1GPR139 | |
| SCHEMBL17452687 | 0.71 | PDGFRA (0.38) | PTGER1 | |
| SCHEMBL15541535 | 0.70 | CFD (0.48) | CFDKMT2AMEN1RAB9A | |
| SCHEMBL2212756 | 0.70 | SSTR5 (0.42) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562909-B1 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK SHARP & DOHME (US) | 2012-06-27 | — | — | EP | disclosed |