SCHEMBL10074284

SCHEMBL10074284

CC(C)(CNC(=O)CC(Cc1cc(F)ccc1F)NC(=O)C(C)(C)C)CNC(=O)[C@@H](O)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 3/20 0.35
CTSB P07858 3/20 0.34
CTSD P07339 4/20 0.33
REN P00797 2/20 0.33
MMP12 P39900 1/20 0.33
PSMB11 A5LHX3 1/20 0.33
PSMD11 O00231 1/20 0.33
PSMD12 O00232 1/20 0.33
PSMD14 O00487 1/20 0.33
PSMA7 O14818 1/20 0.33
PSMD3 O43242 1/20 0.33
PSMC3 P17980 1/20 0.33
PSMB1 P20618 1/20 0.33
PSMA1 P25786 1/20 0.33
PSMA2 P25787 1/20 0.33
PSMA3 P25788 1/20 0.33
PSMA4 P25789 1/20 0.33
PSMB8 P28062 1/20 0.33
PSMB9 P28065 1/20 0.33
PSMA5 P28066 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10074317 1.00 CTSS (0.35) CTSSCTSBCTSDRENMMP12
SCHEMBL10078386 1.00 CTSS (0.35) CTSSCTSBCTSDRENMMP12
SCHEMBL10078261 0.92 PSMB11 (0.38) CTSSCTSBCTSDRENMMP12
SCHEMBL10078263 0.92 CTSS (0.35) CTSSCTSBCTSDRENMMP12
SCHEMBL10074725 0.91 CTSS (0.35) CTSSCTSBCTSDRENMMP12
SCHEMBL10074997 0.90 PSMB1 (0.38) CTSSCTSBRENPSMB11PSMA7
SCHEMBL10074153 0.90 PSMB1 (0.38) CTSSCTSBRENPSMB11PSMA7
SCHEMBL10074135 0.89 CTSS (0.35) CTSSCTSBCTSDPSMB5MC4R
SCHEMBL10074460 0.89 CTSS (0.42) CTSSCTSDRENSCN9ABACE1
SCHEMBL10074141 0.89 CTSS (0.42) CTSSCTSDRENSCN9ABACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2418196-A1 Dual alanyl-aminopeptidase and dipeptidyl-peptidase IV inhibitors IMTM GmbH (DE) 2012-02-15 EP disclosed