Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 6/20 | 0.55 |
| ▸ | MMP9 | P14780 | 6/20 | 0.55 |
| ▸ | MMP12 | P39900 | 6/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | DDX3X | O00571 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229730 | 0.93 | TSHR (0.56) | TSHRTDP1L3MBTL1MMP2MMP9 | |
| SCHEMBL8228124 | 0.84 | TSHR (0.60) | TSHRTDP1L3MBTL1CHRM2CHRM1 | |
| SCHEMBL10049369 | 0.83 | MMP2 (0.58) | TSHRTDP1L3MBTL1MMP2MMP9 | |
| SCHEMBL315528 | 0.79 | MMP2 (0.65) | TDP1L3MBTL1MMP2MMP9MMP12 | |
| 1,4-Dimethoxybenzene SCHEMBL27381899 | 0.78 | ALDH1A1 (0.82) | TSHRTDP1L3MBTL1DDX3XMAPK1 | |
| SCHEMBL27971902 | 0.78 | ALDH1A1 (0.77) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL29092613 | 0.78 | TSHR (0.75) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL10049366 | 0.76 | MMP2 (0.49) | TSHRTDP1L3MBTL1MMP2MMP9 | |
| SCHEMBL315581 | 0.75 | NPC1 (0.59) | TDP1L3MBTL1MMP2MMP9MMP12 | |
| SCHEMBL8228138 | 0.74 | MMP2 (0.59) | TSHRTDP1L3MBTL1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | SERPINB1, ZFX, MMP2 | TSHR 735/4885TDP1 1289/4885L3MBTL1 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.