Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067671 | 0.85 | ALDH1A1 (0.42) | PARP14KDM4EGAAMAPTMEN1 | |
| SCHEMBL13842610 | 0.81 | QTRT1 (0.41) | — | |
| SCHEMBL15180107 | 0.78 | PARP1 (0.39) | PARP1PARP14KDM4EMAPTMEN1 | |
| SCHEMBL10209809 | 0.78 | TNKS2 (0.45) | PARP1PARP14KDM4EGAAMAPT | |
| SCHEMBL15180115 | 0.78 | TNKS2 (0.45) | PARP1PARP14KDM4EGAAMAPT | |
| SCHEMBL989078 | 0.77 | GRIN2D (0.40) | PARP1PARP14KDM4EGAAMAPT | |
| SCHEMBL6585979 | 0.75 | KDM4E (0.41) | PARP1PARP14KDM4ERECQL | |
| SCHEMBL3674777 | 0.74 | KDM4E (0.43) | PARP1PARP14KDM4EMAPTMEN1 | |
| SCHEMBL3674775 | 0.74 | KDM4E (0.43) | PARP1PARP14KDM4EMAPTMEN1 | |
| SCHEMBL431949 | 0.74 | MAPT (0.37) | PARP1PARP14KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087888-A2 | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT | ONYX PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |