Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10074706 | 0.85 | PARP1 (0.37) | ALDH1A1KDM4EGAATDP1PARP14 | |
| SCHEMBL13842610 | 0.79 | QTRT1 (0.41) | — | |
| SCHEMBL1343569 | 0.76 | PARP1 (0.40) | ALDH1A1KDM4ETDP1PARP14MAPT | |
| SCHEMBL1038155 | 0.76 | PARP1 (0.40) | ALDH1A1KDM4ETDP1PARP14MAPT | |
| SCHEMBL10209684 | 0.75 | SMN1; SMN2 (0.35) | KDM4EGAATDP1PARP14THRB | |
| SCHEMBL10209809 | 0.73 | TNKS2 (0.45) | KDM4EGAATDP1PARP14THRB | |
| SCHEMBL15180115 | 0.73 | TNKS2 (0.45) | KDM4EGAATDP1PARP14THRB | |
| SCHEMBL989215 | 0.73 | MAPT (0.38) | ALDH1A1KDM4EPARP14MAPTPOLB | |
| SCHEMBL24792433 | 0.72 | KDM4E (0.67) | ALDH1A1KDM4EGAATDP1THRB | |
| SCHEMBL988272 | 0.72 | DHFR (0.37) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2293807-B1 | CYCLOPENTA[G]QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF RHEUMATOID ARTHRITIS OR ACUTE MYELOID LEUKAEMIA | BTG INT LTD (GB) | 2012-05-09 | — | — | EP | disclosed |
| US-7250511-B2 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2007-07-31 | — | — | US | disclosed |