Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30681284 | 0.79 | DRD2 (0.53) | DRD2DRD4MAPTKDM4ECA12 | |
| SCHEMBL28429360 | 0.79 | DRD2 (0.53) | DRD2DRD4MAPTKDM4ECA12 | |
| SCHEMBL24365114 | 0.76 | MAPT (0.41) | DRD2DRD4MAPTKDM4ECA12 | |
| SCHEMBL20656848 | 0.75 | DRD2 (0.49) | DRD2DRD4KDM1A | |
| SCHEMBL5586163 | 0.75 | QDPR (0.50) | DRD2DRD4 | |
| SCHEMBL20656845 | 0.75 | DRD2 (0.49) | DRD2DRD4KDM1A | |
| SCHEMBL21447689 | 0.73 | PNMT (0.53) | DRD2 | |
| SCHEMBL30681330 | 0.73 | DRD2 (0.46) | DRD2DRD4 | |
| SCHEMBL22506837 | 0.73 | DRD2 (0.46) | DRD2DRD4MAPTKDM4EHRH3 | |
| SCHEMBL5586162 | 0.73 | DRD2 (0.46) | DRD2DRD4MAPTKDM4ECA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |