Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13086065 | 1.00 | LMNA (0.42) | LMNAPPARGPOLBL3MBTL1HTT | |
| SCHEMBL10075125 | 1.00 | LMNA (0.42) | LMNAPPARGPOLBL3MBTL1HTT | |
| SCHEMBL27295163 | 0.93 | PPARG (0.46) | LMNAPPARGPOLBL3MBTL1HTT | |
| SCHEMBL16311779 | 0.86 | LMNA (0.40) | LMNAPPARGPOLBL3MBTL1HTT | |
| SCHEMBL14143601 | 0.85 | LMNA (0.40) | LMNAPPARGPOLBL3MBTL1HTT | |
| SCHEMBL9650127 | 0.76 | LMNA (0.43) | LMNAPPARGPOLBL3MBTL1HTT | |
| SCHEMBL9036447 | 0.71 | TBXAS1 (0.44) | SMN1; SMN2 | |
| SCHEMBL9472718 | 0.71 | TBXAS1 (0.44) | SMN1; SMN2 | |
| SCHEMBL11075357 | 0.69 | CYSLTR2 (0.44) | LMNAPPARGPOLBL3MBTL1NPSR1 | |
| SCHEMBL3993752 | 0.69 | NFE2L2 (0.58) | LMNANPSR1CYP1A2GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288110-A1 | PPAR MODULATORS | EVOLVA SA (CH) | 2014-09-25 | — | — | US | disclosed |
| US-20140288110-A1 | PPAR MODULATORS | EVOLVA SA (CH) | 2014-09-25 | — | — | US | disclosed |
| US-20120142766-A1 | SUBSTITUTED 1,3-DIOXANES AND THEIR USES | EVOLVA SA (CH) | 2012-06-07 | — | — | US | disclosed |
| US-20120142766-A1 | SUBSTITUTED 1,3-DIOXANES AND THEIR USES | EVOLVA SA (CH) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142766-A1 | SUBSTITUTED 1,3-DIOXANES AND THEIR USES | TBXA2R, PPARG, PPARA | LMNA 1823/4885PPARG 2/4885POLB 2104/4885 |
| US-20140288110-A1 | PPAR MODULATORS | PPARD, PPARG, PPARA | LMNA 3708/4885PPARG 2/4885POLB 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.