SCHEMBL10075465

SCHEMBL10075465

N#C/N=C1\c2ccccc2-c2nc3nc(C#N)c(C#N)nc3nc21

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
USP8 P40818 17/20 0.52
USP7 Q93009 6/20 0.49
USP47 Q96K76 4/20 0.49
MAPK8 P45983 1/20 0.33
MAPK9 P45984 1/20 0.33
MAPK10 P53779 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10075452 0.92 USP8 (0.60) USP8USP7USP47
SCHEMBL10050439 0.81 USP8 (0.50) USP8USP7USP47MAPK8MAPK9
SCHEMBL10075463 0.76 IDO1 (0.43) USP8USP7USP47
SCHEMBL1512605 0.76 USP8 (0.60) USP8USP7USP47MAPK8MAPK9
SCHEMBL10050483 0.76 USP8 (0.83) USP8USP7USP47
SCHEMBL12247600 0.76 ALDH1A1 (0.42) USP8USP7USP47
SCHEMBL1512606 0.76 USP8 (0.60) USP8USP7USP47MAPK8MAPK9
SCHEMBL12342906 0.75 USP8 (0.47) USP8USP7USP47
SCHEMBL1512553 0.73 USP8 (0.58) USP8USP7USP47
SCHEMBL1512554 0.73 USP8 (0.58) USP8USP7USP47

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119828-B2 Material for an organic electroluminescence device and an organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2012-02-21 US disclosed
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-02-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE AFF4, KCNH3, HCN4 USP8 4307/4885USP7 4265/4885USP47 4258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.