Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.53 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP9 | P14780 | 5/20 | 0.53 |
| ▸ | MMP1 | P03956 | 4/20 | 0.53 |
| ▸ | MMP3 | P08254 | 4/20 | 0.53 |
| ▸ | MMP7 | P09237 | 4/20 | 0.53 |
| ▸ | EEF2K | O00418 | 3/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10076139 | 0.82 | MMP2 (0.54) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL10076151 | 0.80 | EEF2K (0.52) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL8277063 | 0.77 | MMP13 (0.60) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL7374552 | 0.76 | MMP13 (0.64) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL9595491 | 0.75 | MMP13 (0.50) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL10076152 | 0.74 | MEN1 (0.59) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL8091795 | 0.73 | MMP2 (0.56) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL6323240 | 0.71 | MMP13 (0.53) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL6323244 | 0.71 | MMP13 (0.53) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL28690186 | 0.70 | TDP1 (0.72) | MMP13MMP2MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093231-B2 | Sulfonylethyl phosphorodiamidates | TELIK, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20080039429-A1 | SULFONYLETHYL PHOSPHORODIAMIDATES | TELIK, INC. | 2008-02-14 | — | — | US | disclosed |
| US-7262182-B2 | Sulfonylethyl phosphorodiamidates | TELIK, INC. (US) | 2007-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039429-A1 | SULFONYLETHYL PHOSPHORODIAMIDATES | MTAP, TYMP, PHOSPHO1 | MMP13 4661/4885MMP2 4669/4885MMP9 4231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.