Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30682124 | 0.81 | LOXL2 (0.32) | LOXL2EGFR | |
| SCHEMBL30682141 | 0.75 | CCR1 (0.40) | CYP2D6EGFRCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL10200834 | 0.75 | CCR1 (0.40) | CYP2D6EGFRCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL14154763 | 0.75 | NOS3 (0.34) | — | |
| SCHEMBL31374504 | 0.73 | LOXL2 (0.41) | CYP2D6LOXL2EGFRCYP1A2USP2 | |
| SCHEMBL9911118 | 0.73 | LOXL2 (0.41) | CYP2D6LOXL2EGFRCYP1A2USP2 | |
| SCHEMBL8277937 | 0.73 | KDM4C (0.46) | CYP2C19CYP2D6CYP2E1CYP2C8CYP2A6 | |
| SCHEMBL14347700 | 0.73 | RPS6KB1 (0.35) | — | |
| SCHEMBL26524988 | 0.71 | KCNH2 (0.36) | — | |
| SCHEMBL18791502 | 0.71 | NOS3 (0.38) | CYP2C19CYP2D6CYP2E1CYP2C8CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081922-B1 | 5,6-Ring annulated indole derivatives and use thereof | SCHERING CORP (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2008136815-A2 | 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-11-13 | — | — | WO | disclosed |