Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18123545 | 0.85 | KCNH2 (0.39) | KCNH2HRH4HRH3ALDH1A1HRH2 | |
| SCHEMBL31347405 | 0.77 | ALDH1A1 (0.38) | KCNH2HRH4HRH3ALDH1A1HRH2 | |
| SCHEMBL31347400 | 0.77 | ALDH1A1 (0.38) | KCNH2HRH4HRH3ALDH1A1HRH2 | |
| SCHEMBL18123538 | 0.75 | CYP1A2 (0.41) | KCNH2HRH4HRH3ALDH1A1CYP1A2 | |
| SCHEMBL29967583 | 0.75 | HSD17B10 (0.38) | KCNH2HRH4HRH3HRH2HRH1 | |
| SCHEMBL29967332 | 0.73 | DYRK1A (0.38) | KCNH2HRH4HRH3ALDH1A1CYP1A2 | |
| SCHEMBL12064494 | 0.73 | EGFR (0.55) | EGFRCYP1A2 | |
| SCHEMBL12909563 | 0.72 | CYP1A2 (0.42) | EGFRALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL127479 | 0.72 | EGFR (0.50) | EGFRMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL22778437 | 0.72 | DGAT1 (0.39) | EGFRPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081922-B1 | 5,6-Ring annulated indole derivatives and use thereof | SCHERING CORP (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2008136815-A2 | 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-11-13 | — | — | WO | disclosed |