Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18405548 | 0.84 | NPC1 (0.57) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL8349985 | 0.83 | ALDH1A1 (0.73) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL12301918 | 0.83 | LMNA (0.73) | KMT2ATSHRRAB9AMAPTNPC1 | |
| SCHEMBL10872891 | 0.82 | NPC1 (0.55) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL10076734 | 0.82 | RAB9A (0.56) | KMT2ARAB9AMAPTNPC1MEN1 | |
| SCHEMBL8202479 | 0.81 | RAB9A (0.71) | KMT2ATSHRRAB9AMAPTNPC1 | |
| SCHEMBL5636368 | 0.81 | NPC1 (0.62) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL16248437 | 0.81 | LMNA (0.70) | KMT2ARAB9AMAPTNPC1POLB | |
| Hydrochloric Acid SCHEMBL10872988 | 0.81 | NPC1 (0.54) | KMT2ARAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL8113903 | 0.81 | ALDH1A1 (0.60) | KMT2ARAB9ANPC1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022780-A1 | 18-BETA-GLYCYRRHETINIC ACID DERIVATIVES WITH ANTI-TUMOR ACTIVITY | Université Libre de Bruxelles (BE) | 2012-02-23 | — | — | WO | disclosed |