Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 3/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | TERT | O14746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294734 | 0.86 | KDM4E (0.57) | NFKB1KMT2ABLMHDAC3HDAC1 | |
| SCHEMBL10261106 | 0.84 | CA12 (0.49) | NFKB1KMT2ABLMMEN1HDAC3 | |
| SCHEMBL3861146 | 0.84 | MAOB (0.81) | NFKB1TSHRCYP1A2MAOBKMT2A | |
| SCHEMBL749730 | 0.83 | MAOB (0.60) | NFKB1TSHRCYP1A2MAOBKMT2A | |
| SCHEMBL751542 | 0.83 | ALDH1A1 (0.57) | NFKB1TSHRCYP1A2MAOBKMT2A | |
| SCHEMBL748843 | 0.82 | MEN1 (0.61) | NFKB1TSHRCYP1A2MAOBKMT2A | |
| SCHEMBL13092061 | 0.81 | MAOB (0.66) | NFKB1TSHRCYP1A2MAOBKMT2A | |
| SCHEMBL958453 | 0.80 | MPO (0.55) | CYP1A2KMT2ABLMPMP22MEN1 | |
| SCHEMBL11196763 | 0.80 | ALDH1A1 (0.64) | NFKB1TSHRCYP1A2MAOBKMT2A | |
| SCHEMBL26197859 | 0.80 | HDAC3 (0.46) | NFKB1TSHRKMT2ABLMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138209-B2 | Substituted picolinamides as MAO-B inhibitors useful for treating obesity | JENRIN DISCOVERY, INC. (US) | 2012-03-20 | — | — | US | disclosed |