Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.59 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 2/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779813 | 0.84 | ALDH1A1 (0.47) | ANPEPENPEPALDH1A1CA12CA1 | |
| SCHEMBL1053349 | 0.84 | KMT2A (0.52) | ANPEPENPEPALDH1A1TSHRTPH1 | |
| SCHEMBL10282665 | 0.84 | KMT2A (0.52) | ANPEPENPEPALDH1A1TSHRTPH1 | |
| SCHEMBL14669312 | 0.81 | CES2 (0.41) | ANPEPENPEPDPP4TPH1SLC7A5 | |
| SCHEMBL9367897 | 0.80 | SLC7A5 (0.53) | ALDH1A1TPH1SLC7A5 | |
| SCHEMBL29098741 | 0.80 | ANPEP (0.67) | ANPEPENPEPALDH1A1FOLH1DPP4 | |
| SCHEMBL8952285 | 0.80 | PRSS1 (0.50) | ALDH1A1 | |
| SCHEMBL7450129 | 0.80 | PRSS1 (0.50) | ALDH1A1 | |
| SCHEMBL7140360 | 0.80 | PRSS1 (0.50) | ALDH1A1 | |
| SCHEMBL14640313 | 0.80 | ANPEP (0.63) | ANPEPENPEPFOLH1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052121-B1 | WNT COMPOSITIONS AND METHODS FOR PURIFICATION | UNIV LELAND STANFORD JUNIOR (US) | 2023-02-22 | — | — | EP | disclosed |
| US-20170281720-A1 | PEPTIDOMIMETIC MACROCYCLES | HOFFMANN-LA ROCHE, INC. | 2017-10-05 | — | — | US | disclosed |
| WO-2017044633-A1 | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 | AILERON THERAPEUTICS, INC. (US) | 2017-03-16 | — | — | WO | disclosed |
| WO-2013123266-A1 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | WO | disclosed |
| WO-2012173846-A2 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012021875-A1 | PEPTIDOMIMETIC MACROCYCLES WITH TRIAZOLE LINKERS | AILERON THERAPEUTICS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012021874-A1 | PEPTIDOMIMETIC MACROCYCLES WITH THIOETHER LINKERS | AILERON THERAPEUTICS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281720-A1 | PEPTIDOMIMETIC MACROCYCLES | TP53, MDM2, MDM4 | ANPEP 319/4885ENPEP 872/4885ALDH1A1 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.