Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497160 | 0.81 | EGLN1 (0.58) | EGFRSRCKDM4E | |
| SCHEMBL2493420 | 0.79 | L3MBTL1 (0.48) | TP53MAPTRXFP1ALDH1A1POLB | |
| SCHEMBL14034926 | 0.79 | KMT2A (0.45) | MAPTRXFP1KDM4EL3MBTL1 | |
| SCHEMBL10079692 | 0.78 | L3MBTL1 (0.45) | TP53MAPTRXFP1ALDH1A1POLB | |
| SCHEMBL24864719 | 0.73 | ALDH1A1 (0.40) | TP53MAPTRXFP1ALDH1A1KDM4E | |
| SCHEMBL35212365 | 0.73 | ALDH1A1 (0.74) | TP53MAPTALDH1A1EGFRSRC | |
| SCHEMBL10962357 | 0.73 | ALDH1A1 (0.74) | TP53MAPTALDH1A1EGFRSRC | |
| SCHEMBL12170772 | 0.71 | MAPT (0.49) | TP53MAPTRXFP1ALDH1A1KDM4E | |
| SCHEMBL1890099 | 0.71 | MAPT (0.57) | TP53MAPTRXFP1ALDH1A1KDM4E | |
| SCHEMBL2294425 | 0.69 | LIMK1 (0.53) | TP53MAPTLIMK1IKBKBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150251-B9 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2150251-B1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2012-06-27 | — | — | EP | disclosed |