Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493420 | 0.86 | L3MBTL1 (0.48) | L3MBTL1KDM4EALDH1A1HTTTP53 | |
| SCHEMBL14034926 | 0.82 | KMT2A (0.45) | L3MBTL1KDM4EHTTMAPTRXFP1 | |
| SCHEMBL2497160 | 0.79 | EGLN1 (0.58) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL10079664 | 0.78 | TP53 (0.44) | L3MBTL1KDM4EALDH1A1TP53MAPT | |
| SCHEMBL24864719 | 0.66 | ALDH1A1 (0.40) | KDM4EALDH1A1HTTTP53MAPT | |
| SCHEMBL15419083 | 0.66 | L3MBTL1 (0.77) | L3MBTL1KDM4EALDH1A1HTTTP53 | |
| SCHEMBL12170772 | 0.64 | MAPT (0.49) | KDM4EALDH1A1HTTTP53MAPT | |
| SCHEMBL1890099 | 0.64 | MAPT (0.57) | KDM4EALDH1A1HTTTP53MAPT | |
| SCHEMBL2383759 | 0.63 | L3MBTL1 (0.76) | L3MBTL1KDM4EALDH1A1HTTTP53 | |
| SCHEMBL12254385 | 0.63 | L3MBTL1 (0.72) | L3MBTL1KDM4EALDH1A1HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150251-B1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2008137060-A1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |