SCHEMBL10079673

SCHEMBL10079673

NCc1cc(Cl)cc(CN2CCC(CN)CC2)c1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 2/20 0.51
ALDH1A1 P00352 3/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
ATM Q13315 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GLA P06280 1/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47
HTT P42858 1/20 0.47
CCR5 P51681 1/20 0.44
PRMT6 Q96LA8 1/20 0.41
CCR3 P51677 1/20 0.41
KCNH2 Q12809 1/20 0.39
CACNA1I Q9P0X4 1/20 0.39
NCF1 P14598 1/20 0.39
SIGMAR1 Q99720 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31540781 0.86 CXCR4 (0.50) CXCR4ALDH1A1L3MBTL1ATMKDM4E
SCHEMBL10079263 0.86 L3MBTL1 (0.47) ALDH1A1L3MBTL1ATMKDM4EGLA
SCHEMBL10079679 0.82 CYP2D6 (0.42) ALDH1A1L3MBTL1KDM4EGAAPRMT6
SCHEMBL4848099 0.80 ALDH1A1 (0.64) CXCR4ALDH1A1KDM4ECCR5CCR3
SCHEMBL29767413 0.80 MAPT (0.72) CXCR4ALDH1A1L3MBTL1ATMKDM4E
Hydrochloric Acid SCHEMBL29525233 0.79 ALDH1A1 (0.62) CXCR4ALDH1A1KDM4ECCR5CCR3
SCHEMBL2673348 0.76 CXCR4 (0.47) CXCR4ALDH1A1CCR3SIGMAR1
SCHEMBL4034621 0.75 SMN1; SMN2 (0.61) CXCR4ALDH1A1L3MBTL1ATMKDM4E
SCHEMBL6943921 0.75 L3MBTL1 (0.58) ALDH1A1L3MBTL1ATMKDM4EGLA
SCHEMBL1061878 0.75 CCR3 (0.71) CXCR4ALDH1A1L3MBTL1ATMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012020220-A1 COMPOUNDS NOVACTA BIOSYSTEMS LIMITED (GB) 2012-02-16 WO disclosed