Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.35 |
| ▸ | JAK2 | O60674 | 8/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19075431 | 0.86 | JAK2 (0.38) | DGAT1JAK2JAK1TYK2JAK3 | |
| SCHEMBL19601282 | 0.85 | SIGMAR1 (0.43) | DGAT1SIGMAR1 | |
| SCHEMBL13243593 | 0.82 | DGAT1 (0.37) | DGAT1TPH1SIGMAR1 | |
| SCHEMBL14983746 | 0.81 | SIGMAR1 (0.35) | DGAT1JAK2HDAC6HDAC1HDAC3 | |
| SCHEMBL25813723 | 0.81 | LRRK2 (0.38) | DGAT1JAK2JAK1TYK2JAK3 | |
| SCHEMBL1498997 | 0.81 | SIGMAR1 (0.33) | DGAT1JAK2JAK1TPH1SIGMAR1 | |
| SCHEMBL5133827 | 0.81 | JAK2 (0.34) | DGAT1JAK2HDAC6HDAC1HDAC3 | |
| SCHEMBL19075441 | 0.81 | SIGMAR1 (0.44) | DGAT1JAK2HDAC6HDAC1HDAC3 | |
| SCHEMBL99469 | 0.80 | JAK1 (0.33) | DGAT1JAK2JAK1TYK2JAK3 | |
| SCHEMBL16980124 | 0.80 | SIGMAR1 (0.36) | DGAT1JAK2HDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-2348023-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-27 | — | — | EP | disclosed |
| EP-2343299-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-13 | — | — | EP | disclosed |