Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 6/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21665752 | 0.89 | JAK1 (0.34) | LRRK2PIK3CDPIK3CAJAK3JAK2 | |
| SCHEMBL2383469 | 0.85 | JAK2 (0.38) | LRRK2PIK3CDPIK3CAJAK3JAK2 | |
| SCHEMBL6127068 | 0.84 | JAK2 (0.35) | LRRK2PIK3CDPIK3CAJAK3JAK2 | |
| SCHEMBL19601282 | 0.83 | SIGMAR1 (0.43) | LRRK2SCN9ADGAT1SIGMAR1 | |
| SCHEMBL2997635 | 0.83 | JAK2 (0.36) | LRRK2JAK3JAK2JAK1TYK2 | |
| SCHEMBL5133827 | 0.83 | JAK2 (0.34) | JAK3JAK2DGAT1JAK1TYK2 | |
| SCHEMBL5133826 | 0.83 | TPH1 (0.35) | LRRK2JAK3JAK2DGAT1JAK1 | |
| SCHEMBL22343499 | 0.81 | LRRK2 (0.41) | LRRK2PIK3CDPIK3CAJAK3JAK2 | |
| SCHEMBL100799 | 0.81 | DGAT1 (0.35) | JAK3JAK2DGAT1JAK1TYK2 | |
| SCHEMBL6127063 | 0.81 | DGAT1 (0.34) | DGAT1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125373-A1 | METHOD FOR PREPARING RUXOLITINIB AND INTERMEDIATE THEREOF | 江苏威凯尔医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |