Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288707 | 0.88 | MAPT (0.51) | KDM4EPTGS2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3528003 | 0.85 | PLA2G4B (0.62) | PTGS2HSD17B10PLA2G4BSMN1; SMN2 | |
| SCHEMBL7344446 | 0.84 | PLAU (0.54) | KDM4EPTGS2ALDH1A1 | |
| SCHEMBL6566253 | 0.83 | PTPN7 (0.69) | KDM4EPTPN7ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL874138 | 0.83 | KMT2A (0.62) | ALDH1A1CYP1A2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL30360394 | 0.82 | PTPN7 (0.67) | PTPN7ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL2474817 | 0.82 | PTPN7 (0.67) | PTPN7ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL23832436 | 0.81 | RAPGEF3 (0.58) | PTGS2PTPN7HPGDHTT | |
| SCHEMBL10174361 | 0.81 | GAA (0.55) | KDM4EPTGS2PTPN7ALDH1A1CYP1A2 | |
| SCHEMBL5390728 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP2C19MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019106-A2 | POSITIVE AND NEGATIVE MODULATORS OF NMDA RECEPTORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-02-09 | — | — | WO | disclosed |