Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 7/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429537 | 0.92 | PLA2G4B (0.54) | PLA2G4BCA1CA2NPC1POLB | |
| SCHEMBL2116437 | 0.88 | PTGS2 (0.66) | POLBSMN1; SMN2PTGS2HSD17B10MAPT | |
| SCHEMBL10299626 | 0.87 | PTGS2 (0.57) | NPC1POLBRAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL6960461 | 0.85 | L3MBTL1 (0.61) | POLBRAB9APTGS2MAPT | |
| SCHEMBL4262664 | 0.85 | MAPT (0.70) | CA1CA2NPC1POLBRAB9A | |
| SCHEMBL10080489 | 0.85 | KDM4E (0.63) | PLA2G4BSMN1; SMN2PTGS2HSD17B10 | |
| SCHEMBL9327172 | 0.85 | PLA2G4B (0.61) | PLA2G4BPKMTSHRMAPK1SRD5A2 | |
| SCHEMBL2386974 | 0.84 | SMN1; SMN2 (0.60) | NPC1POLBRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL28123483 | 0.84 | MAPT (0.60) | NPC1POLBRAB9ASMN1; SMN2PTGS2 | |
| SCHEMBL7283346 | 0.84 | PTGS2 (0.58) | NPC1POLBRAB9ASMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436201-B2 | Functionalized diphenolics and absorbable polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2013-05-07 | — | — | US | disclosed |
| EP-1523473-B1 | INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-02-27 | — | — | EP | disclosed |
| US-20130041045-A1 | FUNCTIONALIZED DIPHENOLICS AND ABSORBABLE POLYMERS THEREFROM | BEZWADA BIOMEDICAL, LLC (US) | 2013-02-14 | — | — | US | disclosed |
| US-8288505-B2 | Functionalized diphenolics and absorbable polymers therefrom | BEZWADA BIOMEDICAL, LLC (US) | 2012-10-16 | — | — | US | disclosed |
| US-7858616-B2 | Indolinone derivatives substituted in the 6 position, their preparation and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-12-28 | — | — | US | disclosed |
| US-20090197876-A1 | INDOLINONE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-08-06 | — | — | US | disclosed |
| US-7560480-B2 | Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-14 | — | — | US | disclosed |
| US-7547703-B2 | Indoline derivatives substituted in the 6-position, their preparation and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-06-16 | — | — | US | disclosed |
| US-20090118318-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of CCR8 Mediated Diseases | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-5612373-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1997-03-18 | — | — | US | disclosed |
| WO-1995000472-A1 | 1,2 DIACYLATED HYDRAZINE DERIVATIVES AND THEIR USE AS ALL ADHESION INHIBITORS | ZENECA LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |
| EP-0632016-A1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |
| EP-0368912-B1 | POLYANHYDRIDES WITH IMPROVED HYDROLYTIC DEGRADATION PROPERTIES | MASSACHUSETTS INST TECHNOLOGY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5254576-A | Diphenyl-heterocyclic-oxazole as platelet aggregation inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0368912-A4 | POLYANHYDRIDES WITH IMPROVED HYDROLYTIC DEGRADATION PROPERTIES | — | 1990-12-19 | — | — | EP | disclosed |
| EP-0368912-A1 | POLYANHYDRIDES WITH IMPROVED HYDROLYTIC DEGRADATION PROPERTIES. | MASSACHUSETTS INST TECHNOLOGY (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4857311-A | FROM P-CARBOXYPHEN(-OXY OR -YL)ALKANOIC ACID; BIODEGRADABLE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1989-08-15 | — | — | US | disclosed |
| WO-1989000855-A1 | POLYANHYDRIDES WITH IMPROVED HYDROLYTIC DEGRADATION PROPERTIES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1989-02-09 | — | — | WO | disclosed |
| US-4105790-A | ANTICOAGULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130041045-A1 | FUNCTIONALIZED DIPHENOLICS AND ABSORBABLE POLYMERS THEREFROM | DDT, DHCR7, NOTUM | PLA2G4B 1802/4885CA1 2199/4885CA2 2543/4885 |
| US-20090118318-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of CCR8 Mediated Diseases | CCR8, CCR1, CCR10 | PLA2G4B 1397/4885CA1 4546/4885CA2 3858/4885 |
| US-20090197876-A1 | INDOLINONE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | KDR, FLT1, ERBB2 | PLA2G4B 2817/4885CA1 4473/4885CA2 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.