Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530776 | 0.90 | PIK3CD (0.47) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11591 | 0.84 | PRKCH (0.37) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7863 | 0.82 | PIK3CD (0.38) | PIK3CDTAAR1PIN1PRKCHPRKCE | |
| SCHEMBL718113 | 0.82 | PRKCH (0.38) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17530807 | 0.82 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL845139 | 0.80 | PIK3CD (0.53) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL718038 | 0.79 | PIK3CD (0.35) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8072 | 0.77 | SOS1 (0.36) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8073 | 0.76 | KMT2A (0.36) | PIK3CDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL713514 | 0.76 | PIK3CD (0.48) | PIK3CDPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432784-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133836-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-11-25 | — | — | WO | disclosed |