Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.53 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15899852 | 0.81 | PIK3CD (0.42) | PIK3CDCNR2CNR1MAPTKDM4E | |
| SCHEMBL10081 | 0.80 | PIK3CD (0.42) | PIK3CDFAAHTP53PDE4APDE4B | |
| SCHEMBL715607 | 0.77 | CNR2 (0.43) | PIK3CDCNR2CNR1P2RY12MAPT | |
| SCHEMBL8614 | 0.77 | DRD4 (0.45) | PIK3CDFAAHALDH1A1 | |
| SCHEMBL3711668 | 0.76 | MTNR1A (0.39) | PIK3CD | |
| SCHEMBL3716004 | 0.72 | GHSR (0.38) | PIK3CDCNR1MAPTKDM4EALDH1A1 | |
| SCHEMBL714860 | 0.71 | PIK3CD (0.42) | PIK3CDCNR2CNR1P2RY12MAPT | |
| SCHEMBL714861 | 0.71 | PIK3CD (0.42) | PIK3CDCNR2CNR1P2RY12MAPT | |
| SCHEMBL3705670 | 0.71 | PIK3CD (0.43) | PIK3CDKDM4EALDH1A1 | |
| SCHEMBL715606 | 0.71 | CNR2 (0.41) | PIK3CDCNR2CNR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432784-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133836-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-11-25 | — | — | WO | disclosed |