Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | USP28 | Q96RU2 | 7/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 5/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10081 | 0.82 | PIK3CD (0.42) | PIK3CDTAAR1PIN1PRKCHPRKCE | |
| SCHEMBL5299 | 0.79 | SOS1 (0.38) | KDM4EPIN1PRKCHPRKCESOS1 | |
| SCHEMBL5300 | 0.78 | OPRK1 (0.34) | KDM4EIKBKBPRKCHPRKCESOS1 | |
| SCHEMBL17530807 | 0.77 | PIK3CD (0.58) | PIK3CD | |
| SCHEMBL14480684 | 0.75 | SOS1 (0.37) | KDM4EPRKCHPRKCESOS1OPRK1 | |
| SCHEMBL14480681 | 0.75 | SOS1 (0.37) | KDM4EPRKCHPRKCESOS1OPRK1 | |
| SCHEMBL7307 | 0.73 | ALDH1A1 (0.40) | TAAR1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL17530776 | 0.72 | PIK3CD (0.47) | PIK3CDPIN1 | |
| SCHEMBL713514 | 0.71 | PIK3CD (0.48) | PIK3CDKDM4EALDH1A1PRKCHPRKCE | |
| SCHEMBL717881 | 0.71 | SOS1 (0.39) | PRKCHPRKCESOS1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499129-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058108-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |