SCHEMBL1008486

SCHEMBL1008486

COc1cccc(O)c1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.64
KDM4E B2RXH2 2/20 0.64
ALDH1A1 P00352 1/20 0.64
LMNA P02545 1/20 0.64
CYP3A4 P08684 1/20 0.64
MAPT P10636 1/20 0.64
HPGD P15428 1/20 0.64
ALOX15 P16050 1/20 0.64
ALOX12 P18054 1/20 0.64
MAPK1 P28482 1/20 0.64
HSD17B10 Q99714 1/20 0.64
CA1 P00915 4/20 0.60
CA2 P00918 4/20 0.60
TSHR P16473 2/20 0.60
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
CA12 O43570 3/20 0.46
CA7 P43166 3/20 0.46
CA9 Q16790 3/20 0.46
CA14 Q9ULX7 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24855685 0.88 TP53 (0.55) TP53KDM4EALDH1A1LMNACYP3A4
SCHEMBL3790244 0.83 CA1 (0.58) TP53KDM4EALDH1A1LMNACYP3A4
SCHEMBL9454007 0.81 TSHR (0.54) TP53KDM4EALDH1A1LMNACYP3A4
Methoxymethane SCHEMBL10659099 0.80 TSHR (0.59) TP53KDM4EALDH1A1LMNACYP3A4
SCHEMBL26611717 0.79 ALDH1A1 (0.48) TP53KDM4EALDH1A1LMNACYP3A4
SCHEMBL11151784 0.79 MAPK1 (0.48) TP53KDM4EALDH1A1LMNACYP3A4
SCHEMBL691908 0.79 TSHR (0.52) TP53KDM4EALDH1A1LMNACYP3A4
3-Methoxycatechol SCHEMBL29477155 0.78 TP53 (1.00) TP53KDM4EALDH1A1LMNACYP3A4
3-Methoxycatechol SCHEMBL67332 0.78 TP53 (1.00) TP53KDM4EALDH1A1LMNACYP3A4
SCHEMBL4634640 0.78 GRM5 (0.49) TP53KDM4EALDH1A1LMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0299890-B1 PROCESS FOR THE CHLORINATION OF PHENOLIC COMPOUNDS RHONE-POULENC CHIMIE (FR) 1991-12-11 EP claimed
EP-0283411-B1 PROCESS FOR CHLORINATING PHENOLIC COMPOUNDS RHONE-POULENC CHIMIE (FR) 1991-08-07 EP claimed
EP-0255452-B1 PROCESS FOR CHLORINATING PHENOLIC COMPOUNDS RHONE-POULENC CHIMIE (FR) 1990-01-24 EP claimed
EP-0299890-A1 Process for the chlorination of phenolic compounds RHONE-POULENC CHIMIE (FR) 1989-01-18 EP claimed
EP-0283411-A1 Process for chlorinating phenolic compounds RHONE-POULENC CHIMIE (FR) 1988-09-21 EP claimed
EP-0255452-A1 Process for chlorinating phenolic compounds RHONE-POULENC CHIMIE (FR) 1988-02-03 EP claimed
EP-0211775-A1 Process for nitrating phenolic compounds RHONE-POULENC CHIMIE (FR) 1987-02-25 EP claimed
US-20260092052-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2026-04-02 US disclosed
WO-2025026457-A1 MODIFIED FLAVONE COMPOUNDS AND USE THEREOF 苏州格兰科医药科技有限公司 2025-02-06 WO disclosed
CN-119306735-A Organic compound, application thereof and organic electroluminescent device 北京鼎材科技有限公司 2025-01-14 CN disclosed
CN-119118983-A Xanthone compound and intermediate thereof, preparation method, pharmaceutical composition and application 上海药坦药物研究开发有限公司 2024-12-13 CN disclosed
CN-113493442-B Pyrrolidone derivative as glucokinase activator and preparation method and application thereof 天津药物研究院有限公司 2024-11-08 CN disclosed
US-20240109874-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2024-04-04 US disclosed
EP-0055197-A1 Process for the synthesis of metachlorophenols RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-06-30 EP disclosed
EP-0055196-A1 Process for the synthesis of metachlorophenols RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-06-30 EP disclosed
EP-0055198-A1 Process for the synthesis of metachlorophenols RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-06-30 EP disclosed
EP-0050326-A2 Benzo(b)thiophenes HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1982-04-28 EP disclosed
EP-0003295-B1 PHENOXY-PHENOXY-ALKYLCARBOXYLIC ACID DERIVATIVES WITH HERBICIDAL ACTIVITY, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE CIBA-GEIGY AG (CH) 1981-11-25 EP disclosed
EP-0003295-A1 Phenoxy-phenoxy-alkylcarboxylic acid derivatives with herbicidal activity, their preparation, compositions containing them and their use CIBA-GEIGY AG (CH) 1979-08-08 EP disclosed
US-3959388-A Preparation of phloroglucinol or its monomethyl ether ANDENO B.V. (NL) 1976-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109874-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CHRM1, CHRM5, CHRM2 TP53 2500/4885KDM4E 1279/4885ALDH1A1 2868/4885
US-20260092052-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND CHRM1, CHRM2, CHRM4 TP53 4212/4885KDM4E 1132/4885ALDH1A1 2698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.