Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 3/20 | 0.56 |
| ▸ | ANPEP | P15144 | 1/20 | 0.56 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.56 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 3/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21554929 | 1.00 | LAP3 (0.56) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| SCHEMBL20027600 | 1.00 | LAP3 (0.56) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| Hydrochloric Acid SCHEMBL3841624 | 0.99 | LAP3 (0.54) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| Hydrochloric Acid SCHEMBL289721 | 0.99 | LAP3 (0.54) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| Hydrochloric Acid SCHEMBL288950 | 0.99 | LAP3 (0.54) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| SCHEMBL8001760 | 0.94 | TDP1 (0.57) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| SCHEMBL8001145 | 0.94 | TDP1 (0.54) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| SCHEMBL5718258 | 0.93 | TDP1 (0.60) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| Hydrochloric Acid SCHEMBL4394524 | 0.93 | TDP1 (0.53) | LAP3ANPEPRNPEPDNPEPTDP1 | |
| Hydrochloric Acid SCHEMBL17596474 | 0.92 | TDP1 (0.58) | LAP3ANPEPRNPEPDNPEPTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324814-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS INC (US) | 2022-10-13 | — | — | US | disclosed |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| US-20200123114-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | US | disclosed |
| US-20190270770-A1 | DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION | LANDSTEINER GENMED S L | 2019-09-05 | — | — | US | disclosed |
| EP-3523294-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | Blade Therapeutics, Inc. (US) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
| WO-2012021788-A2 | DIPEPTIDE CALPAIN INHIBITORS | BANYAN BIOMARKERS (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123114-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN9, CAPN1 | LAP3 734/4885ANPEP 696/4885RNPEP 933/4885 |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | LAP3 734/4885ANPEP 696/4885RNPEP 933/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | LAP3 1463/4885ANPEP 1311/4885RNPEP 2086/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | LAP3 734/4885ANPEP 696/4885RNPEP 933/4885 |
| US-20220324814-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | CAPNS1, CAPN9, CAPN1 | LAP3 734/4885ANPEP 696/4885RNPEP 933/4885 |
| US-20190270770-A1 | DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION | DPP4, DPP3, DPP8 | LAP3 191/4885ANPEP 58/4885RNPEP 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.