Sugi Predict

Sugi Predict / Compounds / SCHEMBL1008568

SCHEMBL1008568

SCHEMBL1008568

O=C(O)C(CC1CCCC1)n1ncc(Oc2cccc3ccccc23)cc1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SIRT2 Q8IXJ6 1/20 0.41
▸ SIRT1 Q96EB6 1/20 0.41
▸ SIRT3 Q9NTG7 1/20 0.41
▸ KDM2B Q8NHM5 1/20 0.38
▸ MMP1 P03956 1/20 0.38
▸ MMP13 P45452 1/20 0.38
▸ ACP3 P15309 1/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ ALDH1A1 P00352 2/20 0.36
▸ GPBAR1 Q8TDU6 1/20 0.35
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ METAP2 P50579 3/20 0.35
▸ METAP1 P53582 3/20 0.35
▸ CARM1 Q86X55 1/20 0.34
▸ PRMT6 Q96LA8 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1009338 0.91 NR2F2 (0.39) SIRT2SIRT1SIRT3KDM2BKMT2A
SCHEMBL1008676 0.87 GPBAR1 (0.39) KMT2AGPBAR1LMNAF12
SCHEMBL1008789 0.87 KCNH2 (0.40) MEN1KMT2AALDH1A1GPBAR1L3MBTL1
SCHEMBL1007288 0.86 LPAR1 (0.41) METAP2METAP1
SCHEMBL1009403 0.86 LPAR1 (0.41) MEN1KMT2AMETAP2METAP1HPGD
SCHEMBL1008741 0.86 LPAR1 (0.39) KMT2AALDH1A1L3MBTL1METAP2METAP1
SCHEMBL1008265 0.86 FFAR1 (0.40) MEN1KMT2AALDH1A1L3MBTL1METAP2
SCHEMBL1009307 0.86 NPY5R (0.43) KDM2BMETAP2METAP1
SCHEMBL1008584 0.85 HIF1A (0.36) MEN1KMT2AALDH1A1GPBAR1CARM1
SCHEMBL1008070 0.85 PTGDR2 (0.41) MEN1KMT2AALDH1A1METAP2METAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
EP-2268633-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS F. Hoffmann-La Roche AG (CH) 2011-01-05 — — EP disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
WO-2009127544-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2009-10-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS GCK, GCKR, PDXK SIRT2 360/4885SIRT1 405/4885SIRT3 441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.