Sugi Predict

Sugi Predict / Compounds / SCHEMBL1008265

SCHEMBL1008265

SCHEMBL1008265

O=C(O)C(CC1CCCC1)n1ncc(Oc2ccccc2-c2ccccc2)cc1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 1/20 0.40
▸ METAP2 P50579 1/20 0.35
▸ METAP1 P53582 1/20 0.35
▸ CHRNB2 P17787 1/20 0.35
▸ CHRNB4 P30926 1/20 0.35
▸ CHRNA3 P32297 1/20 0.35
▸ CHRNA4 P43681 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.34
▸ HTT P42858 2/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ FFAR4 Q5NUL3 1/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ FABP3 P05413 3/20 0.34
▸ FABP4 P15090 3/20 0.34
▸ PTGIR P43119 1/20 0.34
▸ PTGDR Q13258 1/20 0.34
▸ BRD4 O60885 1/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1008940 0.88 METAP2 (0.34) METAP2METAP1
SCHEMBL1008741 0.88 LPAR1 (0.39) METAP2METAP1ALDH1A1KMT2ATDP1
SCHEMBL1009403 0.88 LPAR1 (0.41) FFAR1METAP2METAP1MEN1KMT2A
SCHEMBL1007288 0.88 LPAR1 (0.41) FFAR1METAP2METAP1EGLN1USP19
SCHEMBL1009307 0.87 NPY5R (0.43) FFAR1METAP2METAP1EGLN1
SCHEMBL1008070 0.87 PTGDR2 (0.41) METAP2METAP1ALDH1A1NPSR1MEN1
SCHEMBL1008568 0.86 SIRT2 (0.41) METAP2METAP1ALDH1A1KDM4EMEN1
SCHEMBL1008604 0.86 METAP2 (0.36) METAP2METAP1
SCHEMBL1007599 0.86 PTGDR2 (0.42) METAP2METAP1PTGDRMEN1KMT2A
SCHEMBL1009332 0.85 FFAR1 (0.43) FFAR1METAP2METAP1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
EP-2268633-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS F. Hoffmann-La Roche AG (CH) 2011-01-05 — — EP disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
WO-2009127544-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2009-10-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS GCK, GCKR, PDXK FFAR1 1977/4885METAP2 1286/4885METAP1 1716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.