Sugi Predict

Sugi Predict / Compounds / SCHEMBL1008070

SCHEMBL1008070

SCHEMBL1008070

O=C(O)C(CC1CCCC1)n1ncc(Oc2ccccc2C2CCCC2)cc1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGDR2 Q9Y5Y4 1/20 0.41
▸ RBP4 P02753 2/20 0.36
▸ HTR1A P08908 3/20 0.36
▸ SLC6A2 P23975 3/20 0.36
▸ SLC6A4 P31645 3/20 0.36
▸ SLC6A3 Q01959 2/20 0.36
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ METAP2 P50579 1/20 0.35
▸ METAP1 P53582 1/20 0.35
▸ CAMKK2 Q96RR4 2/20 0.33
▸ NPY5R Q15761 1/20 0.32
▸ CCR5 P51681 3/20 0.32
▸ CASP1 P29466 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ CAMKK1 Q8N5S9 1/20 0.32
▸ USP2 O75604 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1007599 0.99 PTGDR2 (0.42) PTGDR2RBP4HTR1ASLC6A2SLC6A4
SCHEMBL1009403 0.87 LPAR1 (0.41) MEN1KMT2AMETAP2METAP1NPY5R
SCHEMBL1008741 0.87 LPAR1 (0.39) KMT2AMETAP2METAP1ALDH1A1
SCHEMBL1008265 0.87 FFAR1 (0.40) MEN1KMT2AMETAP2METAP1ALDH1A1
SCHEMBL1007288 0.87 LPAR1 (0.41) METAP2METAP1CCR5
SCHEMBL1009307 0.87 NPY5R (0.43) METAP2METAP1NPY5R
SCHEMBL1008604 0.85 METAP2 (0.36) SLC6A2SLC6A4SLC6A3METAP2METAP1
SCHEMBL1008940 0.85 METAP2 (0.34) SLC6A2SLC6A4SLC6A3METAP2METAP1
SCHEMBL1008568 0.85 SIRT2 (0.41) MEN1KMT2AMETAP2METAP1ALDH1A1
SCHEMBL1009333 0.85 ADRA1A (0.43) HTR1ASLC6A2SLC6A4SLC6A3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
US-8258134-B2 Pyridazinone glucokinase activators HOFFMANN-LA ROCHE INC. (US) 2012-09-04 — — US disclosed
EP-2268633-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS F. Hoffmann-La Roche AG (CH) 2011-01-05 — — EP disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS BERTHEL STEVEN JOSEPH 2009-10-22 — — US disclosed
WO-2009127544-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2009-10-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264434-A1 PYRIDAZINONE GLUCOKINASE ACTIVATORS GCK, GCKR, PDXK PTGDR2 1648/4885RBP4 1340/4885HTR1A 2827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.