Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14428401 | 0.82 | TDP1 (0.35) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL19151354 | 0.77 | — | — | |
| SCHEMBL135290 | 0.76 | TDP1 (0.40) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL9404722 | 0.76 | TDP1 (0.48) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL13893904 | 0.76 | TDP1 (0.38) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL28385480 | 0.74 | ALDH1A1 (0.43) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL882904 | 0.73 | ERN1 (0.57) | ERN1 | |
| SCHEMBL12662683 | 0.73 | ERN1 (0.38) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL3384426 | 0.73 | TDP1 (0.52) | TDP1THRBERN1 | |
| SCHEMBL4940592 | 0.73 | CA12 (0.41) | TDP1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087872-A1 | QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-06-28 | — | — | WO | disclosed |