Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956882 | 1.00 | TDP1 (0.52) | TDP1ALOX15CYP3A4TP53THRB | |
| P-Xylene SCHEMBL28503019 | 0.85 | ACHE (0.46) | TDP1ALOX15CYP3A4TP53THRB | |
| SCHEMBL2888296 | 0.83 | ERN1 (0.52) | TDP1THRBSMN1; SMN2SRCERN1 | |
| SCHEMBL6257642 | 0.82 | TDP1 (0.52) | TDP1ALOX15CYP3A4TP53THRB | |
| SCHEMBL8338685 | 0.77 | TDP1 (0.52) | TDP1ALOX15CYP3A4TP53THRB | |
| SCHEMBL13363012 | 0.77 | TDP1 (0.52) | TDP1ALOX15CYP3A4TP53THRB | |
| SCHEMBL268706 | 0.76 | ALDH1A1 (0.52) | TDP1SMN1; SMN2SRCERN1ALDH1A1 | |
| SCHEMBL9404722 | 0.76 | TDP1 (0.48) | TDP1ALOX15CYP3A4THRBERN1 | |
| SCHEMBL135290 | 0.76 | TDP1 (0.40) | TDP1ALOX15CYP3A4TP53THRB | |
| SCHEMBL21507858 | 0.76 | TDP1 (0.50) | TDP1ALOX15CYP3A4TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| CN-115466212-B | 2-trifluoromethyl quinoline compound and synthetic method and application thereof | 河南农业大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-113620875-B | 3-nitrile quinoline derivative and preparation method thereof | 郑州大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-115466212-A | 2-trifluoromethyl quinoline compound and synthetic method and application thereof | 河南农业大学 | 2022-12-13 | — | — | CN | disclosed |
| EP-3949708-A1 | HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD PEST CONTROL COMPOSITION CONTAINING SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2022-02-09 | — | — | EP | disclosed |
| CN-113620875-A | 3-cyano quinoline derivative and preparation method thereof | 郑州大学 | 2021-11-09 | — | — | CN | disclosed |
| WO-2020203763-A1 | HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD PEST CONTROL COMPOSITION CONTAINING SAME | 住友化学株式会社 | 2020-10-08 | — | — | WO | disclosed |
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | disclosed |
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | disclosed |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2019-06-13 | — | — | US | disclosed |
| US-5106742-A | Camptothecin analogs as potent inhibitors of topoisomerase I | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1992-04-21 | — | — | US | disclosed |
| EP-0480276-A2 | Carbonylaminostyrene derivatives as recording material | BAYER AG (DE) | 1992-04-15 | — | — | EP | disclosed |
| EP-0436653-A4 | SYNTHESIS OF CAMPTOTHECIN AND ANALOGS THEREOF | — | 1992-01-15 | — | — | EP | disclosed |
| EP-0436653-A1 | SYNTHESIS OF CAMPTOTHECIN AND ANALOGS THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991005556-A1 | CAMPTOTHECIN ANALOGS AS POTENT INHIBITORS OF HUMAN COLORECTAL CANCER | RESEARCH TRIANGLE INSTITUTE (US) | 1991-05-02 | — | — | WO | disclosed |
| US-4981968-A | ENZYME INHIBITORS, ANTITUMOR | RESEARCH TRIANGLE INSTITUTE (US) | 1991-01-01 | — | — | US | disclosed |
| WO-1990003169-A1 | SYNTHESIS OF CAMPTOTHECIN AND ANALOGS THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 1990-04-05 | — | — | WO | disclosed |
| US-4894456-A | CYCLIZATION, ESTERIFICATION | RESEARCH TRIANGLE INSTITUTE (US) | 1990-01-16 | — | — | US | disclosed |
| EP-0091240-B1 | ENZYME DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1985-12-27 | — | — | EP | disclosed |
| EP-0091240-A2 | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-10-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | BRD4, DRD4, TH | TDP1 1806/4885ALOX15 4578/4885CYP3A4 60/4885 |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | DERL1, UBQLN1, ADRM1 | TDP1 109/4885ALOX15 3806/4885CYP3A4 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.